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Cellular repair and rejuvenation lab

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The problem: Aging

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Aging is a major and common risk factor for the development of chronic devastating human illnesses such as cancer, neurodegeneration, and heart-related diseases

The Basis: Damage Accumulation

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Repair

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Damage

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Over time, our cells experience a serious imbalance between sustained damage and the effectiveness of their intrinsic repair mechanisms leading to malfunction

The Mission: Promote Cell Repair

Autophagy

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Autophagy is a protective process that recycles surplus and toxic components in our cells promoting health. We aim to understand and find ways to promote autophagy, and related cellular repair processes, to facilitate healthy aging

The Team

José Luis Nieto Torres, Ph.D.

Principal investigator

Denisa Mihaella Manastireanu

PhD Student

We are currently hiring!


Interested candidates please send a resume and cover letter with research goals to José L. Nieto Torres

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Publications

Most Recent

Post-translational modifications of ATG8 proteins - an emerging mechanism of autophagy control.

Nieto-Torres JL, Zaretski S, Liu T, Adams PD, Hansen M. J Cell Sci. 2023


The Autophagy, Inflammation and Metabolism Center international eSymposium - an early-career investigators' seminar series during the COVID-19 pandemic.

Nieto-Torres JL, Durgan J, Franco-Romero A, Grumati P, Guardia CM, Leidal AM, Mandell MA, Towers CG, Wang F. J Cell Sci. 2021


Macroautophagy and aging: The impact of cellular recycling on health and longevity.

Nieto-Torres JL, Hansen M. Mol Aspects Med. 2021


LC3B phosphorylation: autophagosome's ticket for a ride toward the cell nucleus.

Nieto-Torres JL, Encalada SE, Hansen M. Autophagy. 2021


LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes.

Nieto-Torres JL, Shanahan SL, Chassefeyre R, Chaiamarit T, Zaretski S, Landeras-Bueno S, Verhelle A, Encalada SE, Hansen M. Curr Biol. 2021

Beyond Autophagy: The Expanding Roles of ATG8 Proteins.

Nieto-Torres JL, Leidal AM, Debnath J, Hansen M. Trends Biochem Sci. 2021

All

Present

Funding

Past

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Contact

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@cellrepairlab

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Valencia, Spain