Cellular repair and rejuvenation lab
The problem: Aging
Aging is a major and common risk factor for the development of chronic devastating human illnesses such as cancer, neurodegeneration, and heart-related diseases
The Basis: Damage Accumulation
Repair
Damage
Over time, our cells experience a serious imbalance between sustained damage and the effectiveness of their intrinsic repair mechanisms leading to malfunction
The Mission: Promote Cell Repair
Autophagy
Autophagy is a protective process that recycles surplus and toxic components in our cells promoting health. We aim to understand and find ways to promote autophagy, and related cellular repair processes, to facilitate healthy aging
Publications
Most Recent
Post-translational modifications of ATG8 proteins - an emerging mechanism of autophagy control.
Nieto-Torres JL, Zaretski S, Liu T, Adams PD, Hansen M. J Cell Sci. 2023
The Autophagy, Inflammation and Metabolism Center international eSymposium - an early-career investigators' seminar series during the COVID-19 pandemic.
Nieto-Torres JL, Durgan J, Franco-Romero A, Grumati P, Guardia CM, Leidal AM, Mandell MA, Towers CG, Wang F. J Cell Sci. 2021
Macroautophagy and aging: The impact of cellular recycling on health and longevity.
Nieto-Torres JL, Hansen M. Mol Aspects Med. 2021
LC3B phosphorylation: autophagosome's ticket for a ride toward the cell nucleus.
Nieto-Torres JL, Encalada SE, Hansen M. Autophagy. 2021
LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes.
Nieto-Torres JL, Shanahan SL, Chassefeyre R, Chaiamarit T, Zaretski S, Landeras-Bueno S, Verhelle A, Encalada SE, Hansen M. Curr Biol. 2021
Beyond Autophagy: The Expanding Roles of ATG8 Proteins.
Nieto-Torres JL, Leidal AM, Debnath J, Hansen M. Trends Biochem Sci. 2021
All
Present
Funding
Past